Cycles has two GPU rendering modes: CUDA, which is the preferred method for Nvidia graphics cards; and OpenCL, which supports rendering on AMD. OpenCL Status. Cycles supports OpenCL on modern AMD cards, GCN and above. There is limited support for OpenCL on macOS, and. Cycles is not the only area in blender that benefits or can benefit from OpenCL OpenCL Status - Testing - Supported AMD Cards..